Endocrine Abstracts

Background: Premature ovarian failure (POF) is a complex disorder defined as the cessation of ovarian function before or at the age of 40. Although the etiology of POF remains unknown in a large proportion of cases, it has been suggested that variations in the Inhibin α gene (INHA) may affect the ovarian function of women. This study was performed to investigate whether the genetic polymorphisms of the INHA gene are associated with idiopathic POF in a Korean population.</...

Background: Insulin resistance is a core pathophysiology of polycystic ovary syndrome (PCOS). The screening recommendations for type 2 diabetes in PCOS patients have varied according to organizations, but the AE-PCOS Society recommended that a OGTT be performed in obese patients or in lean patients with advanced age (>40 year), with a history of gestational diabetes, or with a family history of type 2 diabetes. Recently, the American Diabetes Association (ADA) newly includ...

Objective: Insulin resistance is a core feature of polycystic ovary syndrome (PCOS), thus, it may be the common link between PCOS and type 2 diabetes (T2DM).Although the etiology of PCOS has not been elucidated, a number of studies have suggested that genetic factors may play important roles in its etiology and pathogenesis. If PCOS and T2DM share a common genetic background, genetic variants determining the risk of T2DM may also be associated with PCOS....